Tài liệu Vai trò của ức chế trong vỏ não đối với sự hình thành tính nhạy cảm theo hướng của các nơron vùng vỏ não cảm giác soma

- 2 - Hp C L y c Treng no © 1U Riaii T(JNG II iiUAN TAI LlS;U 9-57 I - Cd s3 hinh t h a i cua cac qua t r l n h -&c che d ndroa 9-20 ! • Te bao tiTunf^ g i a n Uc chc t r o n g vo nao 2 . GAM - chat t r i m g ^an TSC che t r o n g vo nao 5» Cau t r u e modun va cau t r u e t j p qu-szi I I - Dan l i § u ve cd che t a c d\^t7 Uc che I a n nhau cua ndrun vo nao* I I I - Ciuan nifra ve t r u 3 n g t h y cam va t i n h c h a t d e t e c t o r cua ndron vc nao* 21-26 :6-32 ! • TrUdne; t h y cam cue ndron 2 , Tinh c h a t d e t e c t o r cua ndron vo nao 5 . Gc quan phan t l c h xuc g i e c v i b r i s s 17- Dan l i g u ve ve;l t r o 5c che d o i vci thanl-i tirjh c h a t cua ndron vo n o c . Phan PHt/OlvG I- b\? ulnii 32-57 III PHAP J«GHl£f^ Cl/U Chuan "bj. d^ng v i t t h x n^igna 5b-51 38-39 I I - Kxch t h i c h hTi5n£j taji I I I - Vi d i | n eye duu£. f?e gJii ho^it tLalx dign cua ndron va dung cho v i di^n d i . IV- Ghi d i § n t h e cua ndron va aru' l y cac k e t qua nghien cUu. !• 2. 3. 4. i)^g Dtfng Tinh Tinh histogram vectd-diagrainjii hf so nh§y cam t h e o hudng t h 3 i g i a n tiem t a n g V- ChUdng trinlri t h y e ng;h i§iQ 30-51 « 3 Phan K U T (4UA lY Trang NGfilfiN Chx&jng CtfU I 52-111 3^-70 ©AC T i m DAP Ul^G CUA I^OROi.^ VraG VO ISAO CAtl GlAC-SOriA s o CAP ( S j ) C fxBO K ) I VOI KICH THICH fcliia.'j HOC, KICii TKIGH Od HOC. I - i>l§n t h e dap u^ng t r o n g vung c h i e u cua cd quan x u c giac v i b r i s s . 5^-33 I I - Phan Ung c u a n d r o n vung c h i e u t r o n g vo nao cam g i a c soma Ichi k i c h t h i c h c a c s ^ i v i b r i a e myt CfiCh r i e n g bift. 5'*—63 I I I - Phan tfng c u a n d r o n k h i k i c h t h i c h c a c sOI,Ai^£i HUONG CUA Y£U TO TiiOI GIAN f>01 VOI SU BIfcdfi DOI TR&^. I - By b i e n d o i t i n h n h ^ y cam t h e o hUdng c u a n d r o n difdi t a c dyng cua k i c h t h i c h d o i . 72-76 1 . Sy t h a y d o i t i n h nh§y cam t h e o hUdng 5 c a c n d r o n ng*uyen p h a t khong nlrify cam t h e o hiidng* 2 . Sy t h a y d o i t i n h nhgiy cam t h e o hUdng d c a c n d r o n n g u y e n p h a t nh§y cam t h e o hUdng. I I - I n h h^:fdng cua y e u t o t h 8 i g i a n d o i v d i s y b i e n d o i t i n h n h ^ y cam t h e o hxrdng cua n d r o n . 77-60 1 . t?y x u a t h i ^ n g i a i d o ^ t'iam d a p v ^ g cua n d r o n 2 . Dien b i e n t h 5 i g i a n t r o n g s y b i e n d o i t l n i i n h ^ y cam c u a n d r o n . I I I - C y ^ t h a y d o i t h 3 i g i a n t i e m t a n g c u a p h a n x/ng k h i x u a t h i ^ n t i n h nh§y cam t h e o hUdng d nhung n d r o n von k h o n g nh§y cam t h e o hUdng. ChUdng III . YAl TRO CUA YEU TO KHOWG GI.J^ TBDm tJU BIEN DOI Tliai NHAY Qtili ThiiX; HUOriG 81-84 - 4 - I - i n h hu3ng cua hvTdng k i c h t h i c h d i e u k h i e n d o i v 5 i dap ting hu:ng* 85-87 I I - by b i e n d o i t i n h nh§iy cam t h e o hudng cua cac ndron dtr^i t a c dyng cua k i c h t h i c h d i e u k h i e n l e n cac s g i v i b r i s s co v i t r i khac nhau t r o n g trtf3ng t h y cam. 87-*00 ! • Sy b i e n d o i t i n h nh^y cam cua ndron k h i cac s ^ i v i b r i s s c h i n k i c h t h i c h d i e u khien phan bo d h a i ben cua s^i v i b r i s s chj-u k i c h t h i c h hutig. 2« Sy t h a y d o i t i n h nh§y cam theo hUdng cua ndron k h i t h a y d o i khoang each g i 5 a k i c h t h i c h d i e u k h i e n va k i c h t h i c h h&ig* 3» Sy t h a y d o i t i n h nh§y cam t h e o htfdng cua ndron k h i k i c h t h i c h d i e u khien t a c dgng vao s ^ i v i b r i s s nlm khac hang v d i fi^i chj.u k i c h t h i c h hxhag. Chtfdng IV 101-111 TAG DU14G CUA PICROTOXIK i)OI VOI THUGITG THU CAii VA SU II£I^ ^01 TI^iti KHAY CM: TilEO HUCMG CUA INCHON I - T I C dyng md rgng trtfdng t h y cam cua p i c r o t o x i n d o i v 3 i cac ndron vung c h i e u thugc cd quan nhjn cam tii cac s ^ i vibriss. 101-10 I I - Tac dyng cua p i c r o t o x i n d o i v d i sy b i e n d o i t i n h nh^y 103-10 cam t h e o htidng cua n d r o n . 1 . ^ o i v d i cac ndron nguyen phat nhay cam t h e o htidng 2 . Doi v 5 i cac ndj^on nguyen phat khong nh§y cam t h e o hiidng I I I - By b i e n d o i t h 3 i g i a n tiem t a n g cua phan Ung dxtSi anh htfdng cua p i c r o t o x i n . 108-11 Phan IV MJK fipH K£T qui 112-129 I - Ve d | c t i n h dap ung cua cac ndron n h ^ thong t i n 112-116 tu' cac s ^ i v i b r i s s n&n t r o n g vung cam giac-eoma sd cap ( ^ j ) * I I - Ve s y b i e n d o i t i n h nhay cam t h e o hu5ng cua n d r o n vung vo nao cam giac-soma dudi anli huSng cua k i c h t h i c h doi» 116-12 I I I - Ve anh ^vTdng cua yeu t o t h 8 i g i a n va khong g i a n d o i v 3 i s y b i e n d o i t i u h nh^y cam t h e o hi/dng cua n d r o n . 120-129 ! • by t i c h h^g ve t h 3 i g i a n 2 . Tich h;;p ve Idiong g i a n . Ph^ V K f T LJJ I ^ 130-131 Phan VI ~*~ Ll|nJ Thm KHIO 132-148 « 3« aiMi • ^ C^n^ v ^ «tf p^i&t t r i d a chuof: cuo 000 khog sinh ly bpc» trong nhtiiaf; nacs (^Jn day ainb l y bpc than iclnh da dgt diHyc ahiitxg ffcanh tyu t o l 5 n , do phat b i | n m^t ©5 quy tic td cbi/c ha^t d^Qg cua nad b^ - ccf quan diSu khl^n phtfc tpp va h9an bao nh'u cua g l ^ i t y cbi3a« ItbJmg; vin de cc? ban va co clnb of:.uyeo cic nhif qua t r l n h tfcb bffp cac lu^ne btfiJng cdD» vol t r S cua qua t r l n b ^c chl tronf bop^ <7<^Q£' pbon xp cS d l l u k l ^ , qu^ t r i o b hiob th&nh V9 duy t r l t r i oh^,v*v«** tvt ISu iis Xitiu hut 3^ quan tdm d§c b i g t cua I.P»Pavlov (47) vo ttbilu nh© cinb l y bpc oc'i tlluG c^ Mdn z^ cZ^r nfaif nbleu nlfi$c khgc« Cac aha khaa hpc Vi§t nao cung c5 hiiijpnt; done f^op nboc d^rib trong linb vyc nay ( 1 , 2» 45, 6I)« Tuy v|iy, ban c b i c cti»a qua t r l n b tic ebl« eui^ nbi/ cc^ chl y u l t billn^ phat ^ r i d n VB uac dime ttn:^Dg bd cua qua t r J n b nay v5l qua t r l n h ht?ng pbln oht? t b l nao, t h l troo^' su^t o^t tbo^i gian d a l vln c ^ chiia dif^^ Kit qua ngblln e^u cua nbiSu t^> t b i t a c g i a tr^n pbatD v l coSn t b i g l $ i trong v a i chyc naa g l a day da chfing mlnb v a i t r o bSt siic quan tr;mf; cua qua t r l o b i$c chl dli v5i toan bc» ^^§t troog ahtfng phtfctog pbap co hifu quo dSi v ^ vl#c t i e bl§a vai t r o cua 5c cbl l a pbi^mg pbap v l dlfn d l (mlcroalectropboroa o ^ l i c a t i o n ) , d(^ CDC c b i t d^i icbaoe ( o o t a g w i i t t a ) cua geiw»a-oa5ino-*utyric-axtt (UAES) vao tl bao tb§Q k i n b . £ | c qua ogaien c5u cbo t h i y ay pbong toa Se c b l Be Xao mit t£nb c h i t d e t e c t o r cua nifron (V, &3) • Bgi;PQ^c l a l , cung bSng pfaiJcmg pbap vl di#n dl 6tfe g l u t a ^ e t vao cac ncfrtm aha cacb d i l o ^ l kboaog 200 diet 3CX> mm t b i thay s u i t bi0n cac natron d e t e c t o r m^i, b o | c thay ddi tCob nbay cof& da co t r u ^ dSy cua cac acrron d e t e c t o r (XO)*!ihllQ tac gia cbo r i n g g l u t i ^ a t da boat hoa cac nc^roa 5o cbl trung glaD va k i t qua l a ^ arixat bl0», bo§c tba:7 d d l tlnb nbay cas tbeo bti5ng cim cac t;l bao tbap* • I t l l p tyc tl© b l l u val t r o 5c c h l trong vo oao d^l v5l sy hltxb thnnb tfnh nbay c^a theo hvtm^ cua coc nc?ron vung cac3 g l a c - a o o a t cbune cbl d'a sii dyng is^t phtfcfng pbap DgblSo c5u kbac, dS l a phifo^ phop kich t b i c b d d i . Fbucme |*8P nay cbo phep nghien c5u val t r o cua qua t r l n h 5c c b l xulu bi§n dtf5l aab hating cua kicb t h l c b h«i5og tSa t y nbiSn troD^ vi#c blnb thanb eac tinh c b i t cua oxyroo vung cam giac^aoffla* Md blnb tbufin l y l cbo v i f c nc^bign c5u noy l a b# t b l o g ttbfty cao xuc giac rSu eao ( v l b r l s e ) * Val t r o cua 5o cbl trong vo nao dng nbifm vy cy t b I sau dSy s 1« % b l € n c5u d|ic t i o b dii? 5tm cm cac nc^on vut^ vo oao Cora giac-«osia Bcr d p (Sj^) d l i v5i kich t h l c b t b i c b daog voo cd quau nb^n cam v l b r l a a « 3m fbSn t f c b sy blnb tbanb t i n h nb^y casi tbeo cna Dc^ron diiP^l aob btn^ig cua klcb t h l c b hi^^g tSs do t h l c b d l l u k b l l o gfiy ra* btidng kich % s i s b l l u anb bii^ag cua ylu t l t h ^ l gian d l l v^l ay b i l n 66l t l a b obpy eioD t b e o hiring cua ac^on» 4* IPhSm t l c b d$c t i n h kbdug g i a n cua ay b i l n doi t l n b nbay c ^ tbeo biiwg cua DC^CHI* 5* K ^ l e o c&u anb bifdisg oua p i c r o t o x i n ( c b I t d^l khang cua GABA) d l l vSi sy blnb tbanb t i n h nbay cm tbeo btf^ng va trt/^nc thy coea cua OCJ^OC vung vo nao cam glac-soiBo. qgam do t h I y dtryc boo c h i t cua 5c cbl va val t r o cua no d e l v5i ay blnb tbanb cac tfnh c b l t nay cua nc^on* ^*btmg k i t quo thu diiyc trong c6nt" t r l n b nghiSn nay cbo t h I y rang t c5u - t5c c b l troog vo nao do kich t h l c b hb^mxe t § a t a o r e ^B lam v o l t bi§n bo^c Im thay d d l t l n b nhay eaa tbeo h\i3fne • 8 » cua fibtfn^ ncrron trong vun^ c b l l u cua cllu do cho phep cac nlia nghloti c5u gla tbuy^t rang s t l boo irp co trong t i t CO coc vung vo nao ©51 va l o t l bao trun^: eloa 5c che (13, 19, 6 1 , 9i^. l a , 132, 14G). Can c5 voo c l u t r u e vs d^c d i e s phan nbanh, o^m 1975 ^ n t a g o t h ^ l ('>9» 13^) cbla coc cl bao r p tbanb bal l o ^ l » - Te b^o rp nho, co cac axon cgin, ph§n b l chu tron^ l5p i l cua vo nao» ylu - T I bso r p l 5 n , too nbanh rpn^, ph8n b l tronf- 1 ^ IIX-V cua vo noo, hh%n d|nb nay cun{; phu hyp v5l y k i l n cuo ^orlQ-i'adilo ( 1 - i ) . hi^ixiSc c5u clu t r u e cua t l b^o r p tron^^ v ^ g v ^ d^Jng vo nao nt:i/&l» t a c f:;ia tb*y nhun^: cl bSo any ph&n nbenh trong g l d l ban nbtfnr. phlan tban^ d5n^::, vudnj^ goc v5l chiou t3nl bSl trtmc crtttig taE» liiaunt: phllo noy xu;§n t 5 l5p i l xuSnc l5p V, CO chl§u dot lUuO-^QOU fids va day kboong iS)0 acD* iiscon cuo cl boo r p c l i p xuc v5l cac t l boo tbop ahm ti*oof: phlln« 6 noo khf, naci l^jf73 Glons(ll>) cuut^ quoa s o t t h I y coc bl boo l o p i i V5 I05I Vi, tu'cync t y nhif cl boo r p l5n vo r p nho cua Sentogouhal» Cbun*:^ P^^-^n nhonb cbu ylu vudnt^ coc v5l tbuy t r t ^ c trunj; ti^o* oc»rdn b(/5nc: tblcft tpoof Goc dSn l l g u n£:hien c5u v l anh hiiD'ng 5c chl gitJa cac vung cao gloc i oeo cung phu bjp v^-l coc quan s o t ve pnun nbonli cua t l boo r p , 'Dual onb hi^'ng cua kich boo bpc, blgu qua 5c cbl the hlgn r o c' coc nc^rdn nhm bmt)s: vuctttj £0c v 5 l ranh chtf tb^p ( 7 , ^)m sit hyp phiKfnc pbap cbyp onb t y d^n^ bing phong xg , pbi/otig pbap Golgl Va klnh b i l e vl dlyn t i i , esc toe gla fib|t Ban (147, 1^6) da cho t b i y xlnap gll/a t l boo r p va t l boo tbap CO ban c h i t ^i^i^A (eaffinio-axlno-butyric--8xlt)» DSy la bSng chSn^; nuo bd sun^, cho gia thuylc t l boo r ? lo t l boo truo^: gloo 5c chl trong vo noo» JNgoal t l ho^ r p z ^ , t l bao blnb bul cung^ d(;i^ col la t l bao trung gloc 5c chl tron^j, vo nao, TbSn cua Coc t l bao noy nlo trong I c ^ H , x l l • /ixon cuo t l boo toa nhanh tbanb hlnb nhi/ c h i l e den cbuc ( 4 9 , 1 ^ , 150) vo too re coc xlnap l o o l I I t l l p xuc v&i dopn dIu ax«i cua t l baO tbap ( 1 M , 1 4 5 , 146) • Irong nliung nam gin dSy, cac toe g l a i*hgt Ban ( 145 , 146, 146) c5n thay trong vo nao co bal lo©! t l boo blnb saO khac cung t b i ^ c I09I t l bao trung gian 5c cbl« £0 l a cac t l boo blnb ©gng nb§a va cl boo co bal bo d e n d r l t . v5l pbtrcm^ pbap chvp anb b*ng phong x©, coc coc gla cuasf, thIy boa c h i t trw5g gian cua coc xlnap nay l o GiiBA# Ttf cac din l l § u t r e n , co t h i k i t lu0n rln^s trong vo nao CO nhllu c l bao trur-r; g i a n , Ve nguygn t:1c, coc t l bao nay co kha nang gfiy 5c c h l coc t l boo thop vo coc ve boo khoc, Tuy tbu§c voo v}. t r l zQa cunc cuo coc phSn nhonb cua cbung trSr; t l boo tbap so 05c d j 5c chl co khoc nbau, thI blgn bBng sy suy glsm nhleu bay I t ctf&nf; dy lucng xung d^ng htftyng tSo vo do do d l l u boo qua t r l n b tpo xunp cua t l bao t;bop« 2 . G/>r.4- c b i t trum- glnn 5c chl t r o n r vo n.r|Q . Kbllu y k i l n cho ring c h i t trung gian 5c chl ct^ ban t r o n t vo aoo l a gaomo-afflla^-'butyrlc-oxlt ( > , 5 , 5 8 , 7 1 , 82 , 83, 93, 116). » 13 « Tbeo din l i $ u cua B0t s i t a c glo (55* 5^) ohnc 60 G^}^i trotig noo ttPtmg d e l c a o , Ixboang 1,1-^j ool5/g» I^ung phmmg pbap pbon*.; x j donh ciu ( I r - GABA) Iversen va c^nc sif (112 , 113) cbo b l e t , khoang 70 >v c h i t nay t|ip trun^^ a t?n cung tban k l n h , 11 >» trSn s y l khdUt: co myelin, 11 v^ t r i n dendrlu va 6 ^ ti'Sn cl boo ijlia* 3y t i p trung OAB^ nhlSu t r o n g t#n cung t b i n klnb cb5nci t o no pbal glif vol t r o quan trpng t r o n g din truyin xlnap t o l t^ay. TrOQg nbufng t b l nghi^ra klcb t h l c b t r y c t l l p len bi m$t vo noo, doner th<^l v5l v l f c g h i difn t h I 5c cbl J* ncardn , tac gla da xac djnb duyc non^ d^ cua GABA t;anc Ifin g ^ 3 I a n so v5l l5c cbtia kich thlcb» IJIU kb5 ion Ca**^ tronf; cd than kinb ohl khi klcb t h l c b vo nao nSnt d^J QiiBA khong tling ISn « Dllu noy cb5ng t o Gn"*^ lo ylu cl kbdng cbl t h l l u duyc dl g l a l phone CABA, tiXcPng t y nhu t i n h c h i t cua coc fooa chat trung glon khgc da dtipyc cdc^ nb§n (112, 1 1 3 ) . ^o cvng 1 P B^t bing chSfif^ ou^ d l kb^ t^ng s3 oc?rdn ghi duyc, t i n sS xung glaffl xuong con 0,6 xung trong ns^c g l a y , 6 ogt o l no^on kbnc, xung d^ng libdng xulu blgo, Cgc no^rcn noy do b | 5c cbl bo5n t o o n , TrontT dieu klgn trOn, v5i difn eye gbl dl§n bSn trtmg t l boo, coc coc gia da ghi d; ye dl§n t b l tSnc pbSn c;,^ ( h y p e r p o l a r l z a t i o n ) * I^bti vgy UA£i do gSy tru ph^n eye aong no»rdn a vo noo cut^e t y nhi^ dl$n t b l ijang pb3n eye troni:: xlnap glu-a t l boo tfo cbl iienshaw va t l baa vpn dyng tuy sln^!;* s 14 9 Myt trong nburng pbusmg pbap xac d^nh co blfu quo val t r o trung gian boa bpc cuo GAB/* lo dung cac c h i t d l l kbang ( a n t a g o n i s t ) cua GAB^ t a c dgng len nc?ron ( 7 9 , 6 ^ - ^ , 9 4 , 105, 106, 107, 135, 136)* Gac cdng t r l n b ngbldn cms cus C u r t i s vo c^ng sy (04-66) da cho thay 00*51 tac d^fnp, cuo alcalol^^-blcu culln ( a n t a g o n i s t cua G A B ^ ) , bl^u qua 5c onl cua OABA h% s i t hoan toan* kbdog ahatii^ t b l , nhilu kbl xung ahn cua neuron con t ^ g bG^c blnb thi^4^« l a c gla cbo s&c^, trong d l l u klfn ty nbiSn v5l m^iz m5c dy nao d o , ncfrdn da cf vr&Cf: t h a i b}. 5c c b l , v l t b l cac d^mg cua b l c u c u l l n kbdng nbting pbong toa bl^u qua cua GiB^ so con g l a l pbong nctrdn kbol'*5c cbl truPcfn^ l y c ^ Sou do S l l l l t o (135, 136) vo HlckS (107) kbl ag:hl§n c5u sy b l l n d l l trtf^n^^ thy coo cua ncfrdn vung cao g i a c cunc nb§n tbIy hlfu qua cua GAB^ b} mit boon toon kbl cung m(^t luc cbo CABA va b l c u c u l l n t a c dyng I t o acni'dntf Kit qua t b l nt"bi§ffi cua Stcwat va Cf^ng sy (149) cbo t h | y ngoal blcuculln c ^ co myt lOal o l c a l o l t khac l o p l c r o t o x l a cung lo c h i t d l l khon^-: cua GA3A» i^bl dtfo voo t l bao, cfalt nay cung l a s giom bi^u qua 5c cbl cua G^BA tdcmg ty nbii b l c u c u l l n , Cac cdng t r l n b ngbign c5u gin day n h i t cua Alexandr va c^ng sy ( 9 , IG, 11) cung cnung oinh t a c dpn^: cus p i c r o t o x i n ttfcfng t y nha b l c u c u l l n trong quo t r l n b b l l n d l l trii&ne t h y cam Va t l n b c h i t d e t e c t o r cua ncTcc vung cac g i a c & tseo, Kbl x^^> x l c cac c b I t l a s glao blfu qua 5c c b l cua GijBi Sexkov (55) dya trSn col l l # u thyc ngblfm cua nhilu uoc gla da duPa »» y k i l n v l vol t r o cua p e n l c l l l n , Tbeo dn^, p e n l c l l l n cung l a c h i t d l l khanu cua GABA, CO ^ac d]fn£: Im glam 5c cb cua GAB A trong vo nao» i;o do p e n l c l l l n da d*/yc dung d l too nfaimg Old blnb dpog klnb thyc ngbl^o, GJ Qhi toe dyne d l l kbang cua blcuiitlin vo plcrotcwrln d l i v ^ CAi^ khac nbou« Blcuculln co clu tao tiKfug t y nbu phen ttf GAB/J va cung aha GABA, no k i t hyp v5l **phan nh§c bllt** cua vung thy c a s trSn ©ong neuron* v l vyy ma sy k i t hyp noy c?ang ^ 15 « t l n b c h i t "canb t r o n h " . Con p i c r o t o x i n c b i k i t hyp v5l •*pb5n d l l u boa", nan t a c Cms kbdng tbeo ccr cbl canb tranb (149) • Soog du tbeo ctf cbl nao, cac c b I t d l l kbonc cung locn glao bl^u qua 5c cbl cua GAi>A d l l v5l oOvQn nbif r ^ a u , Dllu do kbing djnb thStn gia tbt^ylt cbo r i n g GABA 1Q c h i t t r u n g gian 5c chl trong vo nao, Tron^i, Coc t|in cung thin klnb i vo nao GABA di/yc tyo r a bIng con dLro^.g ^ c o c b o x l n boa a x l t g l u t a s l c v&l sy tbaQ g l s cua aen g l u t a o e t decacboxylaza vo coenayo Bg (113)• I^ng tbtfl CABA cung duyc *o^ tbu IQX v5i o i l y e It/n (Ko » d^S (K» m 2,2 , 10^5 M) (112, 1 2 4 ) . Bhm^ k i t qua ngblSn c5u v^ slnb l y ncfron, v l t l bao hpc, v l di^c ly hpc va bIng klnii bien vl dlgn ttf da Isisang d].nb GABA CO du vioM chuan myt boa c h i t trun4' glon ifc cbl trong vo nao (55)» GABA diryc too r a tron^: cac xlnap l o a l I I (xlnap 5c c h l ) gllio t l boo sao vo c l boo t h a p i gSy tfu pbSn eye san^: t l bao thop va do do 5c chl kba nSng boat d^ng t y o xung cuo cl bao nay, Nbtf vgy ca ebl 5c cbl cuo te bao triuxg gian d l l v5l t l bao tbap l o nhh chat t r u n c glon hoc bpc GABA, bay nol each khac, 5e chl co ban c b I t G^BA. vl v§y x5 dpnc G^B^ va d|lc b i $ t lo cac a n t a g o n i s t no trooB v l | c nghlSn ctfu quo t r l n b , 5 c cbl lo boan toon ly- cua byp 3» c l u L-ruc mddun vo c l u t r u e tan ouSn ( c n s s a b l e ^ Sy b l l u b l l t v l ntsuySn t i c boat dyng cua tiicg nc^on du c5 pbODt': pbu Vo do dour, din dev vIn kbdng cho pbep nbgn th5c dtfyc dly du cac ntuyOn l y bojjt dgnc cbune* cua ca b^ noo,Cblnh v l v^y ma vlgc ncblon c5u Qg;uyen t a c td cb5o coc agnr. ncfrdn duyc c o l nbi7 cs^Jt bL?5c quan trpng t r o n r vlgc kbass pbo nbifnr b l m§t cua b^ thing t h i n k l n h . ic^ Quan nl|c9 vl sy tBn t a i troue vo noo cac t l boo trung glon 5c cbl CO onb hiftJiag r a t l5n din kbol nlyni bl#n dpi v l sy t<5 cb5c - ebue n^ng vo noo o 5 i , Tbeo kbal nlgo noy tbl cac nc^dn tgp hyp tbonh coc clu tr&i oddun vo cau t r u e tpp quan* • ) f^^*M^ « coc no^dn t§p hyp v5l nhgu tbanb cac cgt hlnb t r y theo chiSu thing d5n^ t p l I s coc raddun, fcfidua glo nbimg t l bao t h i n klnb cung thyc hlgn myt cb5c n^ng tbdng t i n nio do ( 1 6 , 1 9 , ^ 1 , 2 7 , aB, 4 3 , 54, 1 3 I , 1 6 1 ) . Rgu'S^l dSu t l € n d l cgp d i n c l u t r u e mddun trone vo nao l a i^ountcastle (^3) va xi»«ell (131)* Kbl k l c b t h l c b l$fi da 0 k h i , cac t a c gia n b ^ t b l y t r § n vune vo nao cas g i a c co cac cyt ncfrdn bufng p h i c , c^nb do co cac cyt iKd^on 5c c b l • l^bun^i luc do cac |»ac gla trSn cbua g l a l t b l c h dtryc cb5c a&cs cuo coc cyt ncrron nay* ^ u nh^ co sy phot bifn r a coc ncfrdn trung glon 5c chc trr^ig vo nao, quon nl^is v l c l u t r u e cyt din din dtfyc song t o * »b5n^" din l l ^ u ngbien ctfu vh dlgn sinh l y da c b i r o , kbl dlgn eye d l quo cac l^*p cuo vo nao vo ludn ludn vudng goc v5l b l Q§t vo nao, tbt/acg ghi doyc coc wjron g l l n g nhau v l o§t cb5c nang* Cac c^t ncfron co chSc nang c l i n g nbau gbl duyc c? cac vung cm g i a c ( 4 3 ) , vung th% giac ( 1 0 8 ) , vung tblnh g l l e ( 1 4 , 15) vo vung vgc d^n^^:, ( 7 4 , 7 5 ) . ^^bu v0y c l u true c^t l a d^c dllts cbung cua vo noo# Tbuylt clu t r u e cyt ngoy nay duyc g p l l a t b u y l t tsddun, Tbeo ^ o u n t c a s t l e (43) dan v} ccr ban cua oddun lo v l oddun v5l di7^^ klnb gin 30 tsco, Cac ncfron trong ©yt vl reddun co pban 5nt cbpn Ipc v5i myt thorn s i n h I t dj-nb cua k l c b thlcb btf&g rSi3 va lo dc^. vJ. stf cing n b I t cua quo t r l n b xu? l y tbdng t i n * Khoang vol trSm v l sddun t^p b ^ tbonb mddun lt?n, c l c l u C90 ph5c tgp bc/n, l^ddun l5n co dpng p h l l o , d a y kbooog TT; i V-W^#5J « 17 30 - 2G0 Dcm, doi ^^00 - 1000 ocm, xuy§oc5 l5p l i t 5 l l ^ V cuo vo noo* Trong oddun l5n d l l n ro coc quo t r l n b xu" l y tbdn^r t i n pb5c top licfn v5i nhleu thoo s i khnc nhau cuo k l c b thlcb* i>o l o dirn v|. xu ly vo t r u ^ l n dpc t h e r e t i n , t l l p xuc v5i hong l o y t dtfo^i^:; %?ao vn ay^ f^c dwcni ro ('^3)* t>btf v^y, vl n^^uyen t i c cau t a ^ , eac mddun l5n co cs? s^ blnb t h a i tacmr; del r o , nbtfn cac v l ludtiun - dc?n v l cb5c nanf' co* ban - c o kich cbuf5c 3G oco khdnf phu hyp v5l sy phan nbanh cua ogc cyi t h i n klnfi d l til t h a l ^ i u s t 5 l vo noo, Tbeo t a l ll&u dQ dupyc c nj: nhgn (5G), ®0t cyi than kinb thalamus - vo noo tSa nhonb tronr vung c b l l u 6 vo noo trong pbam v l CO diio^T klnli 30U-iiOO ocs vo t l l p ::&; xlnop v ^ gan 5000 ncfron* iJbimg v l ©ddun v5l dMn^ klnb gen 30 oco c b l co t b l boo i^hm 110-260 acfron (^3)* 5y fflSu tbuln tiny chl co cbl g l a l chlcti Khi phat hlfn r a coc t l boo 5c cbl trong jsddun , Cac t l boo 5c ctil difyc bav^s P^l ^^bt^ vvy vl ffiddun l o dcm vJ. cti5c non^^ diPyc hlnb thonii diTol Goc dyne cuo coc t i n hi^u bir5n£. vam^ Hlnb doni; vn k i c h cbtf5c cua no phy thuyc r a t nbiau voo co' s^ blnb thol bsn dau^ libim^:; cd^^ t r l n h ngblcn c5u ve blnb t h a i hpc cuo i-arlnf o d i l l a (122) gop phan c l o l tnlch vol t r o cuo 5c chl trong vo noD del v5l t<^ ch5c - ch5c nan^: cuo coc ©cjdun. Joe gla da figrblen c5u ty o i sy pbjn nbonb cuo t l boo r p trong cac l5p cuo vunc vpn dyng. Axon cuo l o ^ i t e bao noy too nbonb t^ong phao v l nhif^: p h l l o tban^, d5nf: v5l ciileudny khoong 200 f3ca) dal 1000 - SOuO occ;, vudnfv; .:; oc v5l b l (u§i vo nao , xuyen t u l5p Ul din l5p V vS tl^l^^WssMM^'^'o co coc t l boo thop nIo t r o n c phleri. ^''bu wy^by^^hl^^,^^* t;o^ r p - t l sif* *-K1« AZ ^^^ — •**^'>c4f eye no^oti c^:dv*^<9>-?blln^Ai^ae d5rig. a IC Klcb t b i / ^ vo hlnb 6ont, cuo cnc cyt noy do d^c diem ptxbv^ nbonb vo chieu doi cuo oxon co boo r p qvye\^ d^nh, Tbeo Sentagothal (50) trong vo 000 coc raddun co blnb done vn kich thtr5c kbnc nhau l o uuy thuyc voo clu tpo cuo t l boo rp* T I boo r p nho a l5p Xi tao cbonb cac cyt co diwng klnh 50 -• 100 oco, phu byp v ' l klcb thir5c plmo nh^^nh cuo axon. T I boo rp l5n o» l5p I I I tao thirinh coc oddun co dgng pblln,doy kboong 23-3O oco, dal £:ln 5G0 oco vo sau t 5 l5p U d i n 1 ^ V, Tuy cbo din nay vSn cbua co oyt quon d l l a thing; nbIt vl blnb doat:, klcb thu?t'e cua oddun, vl ctf chl coc dyng 5c c b l l | n nbau trong oddun, vo g l i ^ coc oddun, nbi/nr coc cbo ngbldn c5u dIu edng nb^n r i n g ylu ul khdnf: t b l t h l f u dixyc tron£ clu true mddun lo coc uti boo trun?^ fclon 5c c h l , Cac t l b^o noy dong val t r o quoo urpni; tron^^ vl0c v6 cb5c ciou hoo boat dyng cua oedUQ v5i coc o5c dy pii5c typ khsc n h a u , ( 1 6 , 18, 4 9 , 5G , 5 2 , 5^). b) gap Q^h C^aagp^lt) B^n^^ phuc?n^ phop s5 dyne nbllu dlfn eye (c;-5 vl dlpn e y e ) , ghi hOQv tlnb d l | n cuo oyt nhon ncfron, k i t hgp v5i ph\f0tk£ pbgp xoc dj.nb t l n b c h i t va ffi5c dy ti^tii: uac GI^O cbung, oyt s i toe glo (<-tj «. >2, 34) da cbo tboy m^i anb htKm^. cua coc t i n lil^u htf&c^ t § o , troofy cac t^ chSc uhln klnh, oa tr*/5c b l r lo tronr, vo bon c5u djil noo, hlnb thooh c l c t&p quin nc?ron v5l hlnb done' vo klcb thi/'c khac nhou, Tbap Kogon vo c^tc s^ ( ^ , 3Gt 34) t h l c#p quin noron l o oyt ohm coc no?ron cure i trong tr^nf: t h o l biinf: phan, d u ^ bao quoch bSn^ vonb doi coc u l boj bj. 5c c h l , Vg c^v. uruc vonb d.ol QDC V • r.o3 b} t'c c h c , Vo clu t r u e coc typ quan ncfron CO nbl/ng d$c ctiea co* bat^ sau s - tidl c$p quia boo gom coc ncfron cun^; I05I 0' trgng t b s l bimg pblo kinoc nhou vn nao t r e n cun^r myc a5c td ch5c cuo cun*? nbnn x a . th^ia chl lo cung cron ffiyt l5p t l boo, ^ihi; vgy » 19 a (J oSl l5p i:l bjo vo nao cung oyt luc co chc hlnb tbanb nbleu t^p quISn no?ron* 2>o do t^p qu5n co cSu t r u e khccpr c:lon theo c h i l u RcnnCf kboc v5l ofidun co c5u t r u e tbeo c h l l u dpc suit be day cuo vo ooo, - Coc t§p quin CO klcb tbtr5c khac nhau, pby tauyc vao bon chlu va tbdn^ so cuo t i n hlgu h;?^5nf^ t a o , voo n i c thane t l l n boo cuo dyn^r v^t* C dpni: vgc bye th^p (bo s o t , li/5nf: tb§) kich tbif5c coc tgp qoSn r a t l5n (40U - 500 ocm), coo c? d^ng vgt CO VU, dt^^^nr klnh cuo t^p QuBn c h i khoonc. 15^ - *i'X meo. - 1§p quSn c h i blnb thinnh kbl co klcb t h l c b h i ^ g too , vl VQy no kh - Xem thêm -